Engineering platelets for tumour targeting

Engineering platelets for tumour targeting

(2μm), anucleate, discoid-shaped living cells that play essential roles in vascular haemostasis, thrombosis and inflammation [1]. While platelets are primarily confined to blood vessels, they may also accumulate in tumour microenvironments where they modulate functions of both tumour and immune cells [1]. It is known that platelets gain access to tumour microenvironments by passive diffusion ac...

Targeting Platelets for the Treatment of Cancer

The majority of cancer-associated mortality results from the ability of tumour cells to metastasise leading to multifunctional organ failure and death. Disseminated tumour cells in the blood circulation are faced with major challenges such as rheological shear stresses and cell-mediated cytotoxicity mediated by natural killer cells. Nevertheless, circulating tumour cells with metastatic ability...

Tumour Selective Nuclear Targeting in a Tumour

PROGRESSION MODEL 2 3 Michael S. Nastasie, Helmut Thissen, David A. Jans and Kylie M. Wagstaff 4 Nuclear Signalling Laboratory, Dept. Biochemistry and Molecular Biology, Monash 5 University, Clayton, Victoria 3800, Australia 6 CSIRO Molecular and Health Technologies, Bayview Avenue, Clayton, Victoria 3168, 7 Australia 8 Running Title: Tumour selective nuclear targeting 9 10 *Correspondence shou...

The role of platelets in tumour growth.

Platelets, as initial responders to vascular injury, play a very important role in the initial stages of the haemostatic process. While the role of platelets in coagulation has been well studied and documented, their role in other physiological and pathological processes is just emerging. Platelets contain many biologically active molecules and, as they adhere to sites of tumour activated or in...

Thermoresponsive chlorambucil derivatives for tumour targeting.